Female gender as a susceptibility factor for drug-induced liver injury
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Female gender as a susceptibility factor for drug-induced liver injury


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The present article deals with the issue of immune-driven hepatotoxicity in women from different therapeutic drugs. It is seen that females are more exposed to a drug-induced liver injury (DILI) in comparison to men. The injuries are prominent in case of multiple anti-infective drugs as well as therapeutic xenobiotics. 


Article Summary

The effect of the gender-specific influence of CYP450 isozymes is a critical driver that influences drug toxicity. These mechanisms follow a pharmacokinetic principle that enumerates contrasting effects of males and females from a specific drug. Key principle for DILI is driven by reactive metabolite production, immune-based hepatotoxicity as well as changes in mitochondrial actions. HLA (human leukocyte antigen) genes that can modify behaviors of drugs like carbamazepine and abacavir, also influence the link between hepatic and epidermal cells.

Drug toxicity mechanisms

The researchers have developed three primary mechanisms that can justify the exposure of women to liver injuries in response to therapeutic and anti-infective drugs. The first mechanism involves differences based on the gender. The second mechanism highlights the hormones that signal interaction with the drug molecules. This exposes their hepatic cells to adverse reactions like toxicity. The final mechanism is based on the anomalous immune response of women.

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